UpNano
UpNano’s two-photon polymerization (2PP) 3D printing technology enables precise fabrication of complex microfluidic and organ-on-chip platforms with sub-micrometer resolution.
The NanoOne 2PP printer’s ability to print directly inside microfluidic chips, combined with biocompatible materials fully optimized for the platform like HYDROBIOINX® U200, allows the integration of vascular-like channels, membranes and tissue scaffolds essential for physiological modeling. This precision supports the fabrication of realistic organ-level microenvironments for drug testing and disease modeling, accelerating the shift toward animal-free testing and personalized medicine.
A case from Cantoni et al. exemplifies the impact of the NanoOne through their introduction of a custom microfluidic chip to create perfusable microvessels through a two-step method. Their approach enables the rapid creation of 10 μm channels, as shown in Figure a & b, significantly faster than printing the entire construct. Confocal images showcase the formation of a human umbilical vein endothelial cell (HUVEC) monolayer alongside the microchannels, as shown in Figure c & d [1]. Overall, this approach exemplifies how smart fabrication techniques can boost MPL capabilities for creating microphysiological models.
Consortium Non-Members